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Clenbuterol increases lean muscle mass but not endurance in patients with chronic heart failure Clenbuterol, a beta(2)-agonist with potent anabolic properties, has been shown to improve skeletal muscle function in healthy subjects, and in high doses, promotes cardiac recovery in patients with left ventricular assist devices. Clenbuterol increases your risk of heart attacks and other heart damage, and irregular heart rhythms. Additional side effects include muscle tremors, increased perspiration, and blood pressure, insomnia, headache, nausea, and vomiting. The drug can also induce mood changes, agitation, and depression. Clenbuterol, a compound classified as a beta2-adrenoceptor (AR) agonist, has been employed in combination with left ventricular assist devices (LVADs) to treat patients with severe heart failure. Previous studies have shown that chronic administration of clenbuterol affects cardiac excitation-contraction coupling. Abstract Aims: Combined left ventricular assist device (LVAD) and pharmacological therapy has been proposed to favour myocardial recovery in patients with end-stage heart failure (HF). Clenbuterol (Clen), a beta (2)-adrenoceptor (beta (2)-AR) agonist, has been used as a part of this strategy. 017 Abstract Background: High-dose clenbuterol (a selective beta2-adrenergic agonist) has been proposed to promote myocardial recovery during left ventricular assist device (LVAD) support, but its effects on cardiac and skeletal muscle are largely unknown. The fact that an 18% to 20% hypertrophy of the heart was observed confirms other reports 11 and has implications for any future use of clenbuterol in patients with heart failure treated by skeletal muscle assist Women may be more sensitive to the side effects of this medication, such as increased heart rate and shakes, clenbuterol heart failure.

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